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Isolation of two distinct type I angiotensin II receptor genes.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1992 Apr 30; Vol. 184 (2), pp. 1067-73. - Publication Year :
- 1992
-
Abstract
- A rat genomic Southern blot, probed with a type I angiotensin II receptor probe, demonstrated that two highly homologous type I angiotensin II receptors were present. A rat genomic library was subsequently screened and four clones were isolated. From restriction mapping, differential hybridization, polymerase chain reaction amplification and sequence analyses we have determined that there are two unique type I angiotensin II receptor genes. The first of these genes corresponds to the published rat vascular complementary DNA sequence; the second, corresponds to a novel receptor not previously described.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Cattle
DNA isolation & purification
Genetic Variation
Molecular Sequence Data
Oligodeoxyribonucleotides
Oligonucleotides, Antisense
Open Reading Frames
Rats
Restriction Mapping
Sequence Homology, Nucleic Acid
Angiotensin II metabolism
DNA genetics
Receptors, Angiotensin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 184
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 1575725
- Full Text :
- https://doi.org/10.1016/0006-291x(92)90700-u