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[Therapy for overactive detrusor using propiverine].

Authors :
Alloussi S
Goepel M
Richter AE
Eberhardt R
Zwingers T
Brünjes R
Source :
Der Urologe. Ausg. A [Urologe A] 2005 Apr; Vol. 44 (4), pp. 382-6.
Publication Year :
2005

Abstract

Background: Our aim was to evaluate the efficacy and tolerability of propiverine hydrochloride (propiverine) in daily practice and to check the risk-benefit relation using previously collected data on 4,390 patients.<br />Patients and Methods: A total of 2,932 patients with symptoms of overactive bladder were treated with propiverine over a period of 12 weeks using a multicentre post marketing surveillance. At three visits (inclusion, after 4 weeks, after 12 weeks), parameters from the micturition diary (incontinence episodes, frequency of micturition, micturition volume) were recorded.<br />Results: The number of incontinence episodes during daytime decreased during therapy from 3.6+/-3.8 to 1.2+/-2.3. The number of episodes at night decreased from 1.5+/-2.1 to 0.4+/-0.8 (both P<0.001). The mean volume per micturition improved during therapy (from 142.7 ml to 213.3 ml; +49.5%; P<0.0001). Some 85% of the investigators judged the efficacy of propiverine to be good or very good, 2.1% as not sufficient. The most frequent adverse event was dry mouth (17.3% of the patients after 12 weeks) mostly with low severity. More than 70% of the patients reported good or very good tolerability. Only 0.6% of the patients reported insufficient tolerability.

Details

Language :
German
ISSN :
0340-2592
Volume :
44
Issue :
4
Database :
MEDLINE
Journal :
Der Urologe. Ausg. A
Publication Type :
Academic Journal
Accession number :
15754167
Full Text :
https://doi.org/10.1007/s00120-005-0774-z