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[Therapy for overactive detrusor using propiverine].
- Source :
-
Der Urologe. Ausg. A [Urologe A] 2005 Apr; Vol. 44 (4), pp. 382-6. - Publication Year :
- 2005
-
Abstract
- Background: Our aim was to evaluate the efficacy and tolerability of propiverine hydrochloride (propiverine) in daily practice and to check the risk-benefit relation using previously collected data on 4,390 patients.<br />Patients and Methods: A total of 2,932 patients with symptoms of overactive bladder were treated with propiverine over a period of 12 weeks using a multicentre post marketing surveillance. At three visits (inclusion, after 4 weeks, after 12 weeks), parameters from the micturition diary (incontinence episodes, frequency of micturition, micturition volume) were recorded.<br />Results: The number of incontinence episodes during daytime decreased during therapy from 3.6+/-3.8 to 1.2+/-2.3. The number of episodes at night decreased from 1.5+/-2.1 to 0.4+/-0.8 (both P<0.001). The mean volume per micturition improved during therapy (from 142.7 ml to 213.3 ml; +49.5%; P<0.0001). Some 85% of the investigators judged the efficacy of propiverine to be good or very good, 2.1% as not sufficient. The most frequent adverse event was dry mouth (17.3% of the patients after 12 weeks) mostly with low severity. More than 70% of the patients reported good or very good tolerability. Only 0.6% of the patients reported insufficient tolerability.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Causality
Comorbidity
Female
Germany epidemiology
Humans
Male
Middle Aged
Prevalence
Prognosis
Risk Factors
Severity of Illness Index
Treatment Outcome
Benzilates therapeutic use
Muscle Hypertonia drug therapy
Muscle Hypertonia epidemiology
Product Surveillance, Postmarketing
Risk Assessment methods
Urinary Incontinence drug therapy
Urinary Incontinence epidemiology
Subjects
Details
- Language :
- German
- ISSN :
- 0340-2592
- Volume :
- 44
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Der Urologe. Ausg. A
- Publication Type :
- Academic Journal
- Accession number :
- 15754167
- Full Text :
- https://doi.org/10.1007/s00120-005-0774-z