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[Gap junctions, connexins and sudden death caused by coronary heart disease].

Authors :
Zhang SW
Chen XS
Liu SX
Zhang Y
Source :
Fa yi xue za zhi [Fa Yi Xue Za Zhi] 2004; Vol. 20 (4), pp. 250-2.
Publication Year :
2004

Abstract

Gap junctions construct hydrophilic trans-membrane channels which adjust the intercellular communication of chemistry and electricity. In the heart, individual cardiac myocytes are linked by gap junctions. These junctions form low resistance pathways along which the electrical impulse flows rapidly and repeatedly between all the myocardium, ensuring their synchronous contraction. In recent years, some researchers have found that connexins, the protein molecules of gap junction channels, are reduced in number or redistributed from intercalated disks (ID) to lateral cell borders in a variety of cardiac disease, especially in ischemic heart disease. The gap junction remodeling is considered to be arrhythmogenic. These findings will lead us to a new realm in the diagnostic of sudden death caused by coronary heart disease.

Details

Language :
Chinese
ISSN :
1004-5619
Volume :
20
Issue :
4
Database :
MEDLINE
Journal :
Fa yi xue za zhi
Publication Type :
Academic Journal
Accession number :
15751661