Back to Search
Start Over
Identification of an cysteine-to-arginine substitution caused by a single nucleotide polymorphism in the canine monoamine oxidase B gene.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2005 Feb; Vol. 67 (2), pp. 199-201. - Publication Year :
- 2005
-
Abstract
- Monoamine oxidase B catalytically oxidizes biogenic amines such as phenylethylamine and dopamine, and its activity is presumed to be related to particular behavioral traits. In this study, we first identified a single nucleotide polymorphism (T199C) located on the putative third exon of the canine monoamine oxidase B gene, which causes an amino acid substitution from cysteine to arginine. We then examined the allelic frequencies in five dog breeds (Golden Retriever, Labrador Retriever, Maltese, Miniature Schnauzer, and Shiba) and found significant variation among them. The present results suggest that analysis of the monoamine oxidase B polymorphism could be a useful means of elucidating the genetic background of breed-specific behavioral characteristics in dogs.
- Subjects :
- Animals
DNA Primers
Gene Frequency
Mutation, Missense genetics
Polymorphism, Restriction Fragment Length
Reverse Transcriptase Polymerase Chain Reaction veterinary
Sequence Analysis, DNA veterinary
Species Specificity
Dogs genetics
Monoamine Oxidase genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0916-7250
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 15750319
- Full Text :
- https://doi.org/10.1292/jvms.67.199