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Decreased plasma endothelin-1 levels in children with sickle cell disease treated with hydroxyurea.
- Source :
-
Haematologica [Haematologica] 2005 Mar; Vol. 90 (3), pp. 401-3. - Publication Year :
- 2005
-
Abstract
- Plasma endothelin-1 (ET-1) is elevated in patients with sickle cell disease (SCD). Hydroxyurea (HU) is the only drug with demonstrated clinical efficacy in SCD. Here we show that treatment with HU results in a decreased concentration of circulating ET-1 which is not correlated with the HU-induced increase in HbF level. Blunting of the ET-1 vasoconstrictive stimulus could contribute to the beneficial effects of HU.
Details
- Language :
- English
- ISSN :
- 1592-8721
- Volume :
- 90
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Editorial & Opinion
- Accession number :
- 15749673