Back to Search
Start Over
Overexpression of cyclin D1 and interaction between p27Kip1 and tumour thickness predict lymph node metastases occurrence in lower lip squamous cell carcinoma.
- Source :
-
Oral oncology [Oral Oncol] 2005 Mar; Vol. 41 (3), pp. 268-75. - Publication Year :
- 2005
-
Abstract
- We have attempted to identify those subgroups of patients most likely to develop lymph node metastases from squamous cell carcinoma of the lower lip (LLSSC). A total of 97 subjects, who did not undergo elective neck dissection, were recruited into the 60-month disease-free survival study. After univariate analysis, tumour size, histological grading, maximal thickness, perineural invasion and immunoreactivity to cyclin D1 and p27Kip1 proteins proved to be significant factors. Tests of the effect of interaction between p27Kip1 LI and tumour thickness yielded that the impact of tumour thickness on the risk of lymph node metastases was modified by the percentage of p27Kip1 positive cells. Subsequent to models of multivariate analysis, tumour size, positive cyclin D1 protein expression, maximal thickness (> 5 mm), p27Kip1 LI (%) and the interaction term between p27Kip1 LI and tumour thickness retained strong independent predictive values for lymph node metastases. We suggest that immunohistochemistry for cyclin D1 and p27Kip1 may prove to be valuable ancillary tests for identifying LLSSC with metastatic potential.
- Subjects :
- Aged
Aged, 80 and over
Carcinoma, Squamous Cell pathology
Cyclin-Dependent Kinase Inhibitor p27
Female
Humans
Immunohistochemistry methods
Lip Neoplasms pathology
Lymphatic Metastasis
Male
Middle Aged
Prognosis
Regression Analysis
Biomarkers, Tumor analysis
Carcinoma, Squamous Cell chemistry
Cell Cycle Proteins analysis
Cyclin D1 analysis
Lip Neoplasms chemistry
Tumor Suppressor Proteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1368-8375
- Volume :
- 41
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oral oncology
- Publication Type :
- Academic Journal
- Accession number :
- 15743689
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2004.08.014