Back to Search Start Over

Suppression of morphine withdrawal syndrome by interleukin-2 and its gene.

Suppression of morphine withdrawal syndrome by interleukin-2 and its gene.

Authors :
Gu J
Yao M
Wang J
Zhou W
Yang G
Liu H
Zhang Z
Liu X
Source :
Neuroreport [Neuroreport] 2005 Mar 15; Vol. 16 (4), pp. 387-91.
Publication Year :
2005

Abstract

The naloxone-precipitated withdrawal syndrome in mice and rats after intrathecal injection of recombinant human interleukin-2 protein (rIL-2) or its gene was studied. The results showed that rIL-2 could significantly decrease the number of jumps in mice. In rats, rIL-2 significantly suppressed irritating, diarrhea, weight loss, abnormal posture and salivation. Tendencies towards reductions in teeth chewing and dog-shaking were also observed. Furthermore, pcDNA3-IL-2 (8 microg DNA) had a similar effect as 1x10 IU rIL-2 protein on inhibition of morphine withdrawal syndrome in mice, and the expression of rIL-2 protein in spinal cord could be detected for 6 days. These findings provided further evidence for the neuroregulatory function of an immunological molecule such as IL-2.

Details

Language :
English
ISSN :
0959-4965
Volume :
16
Issue :
4
Database :
MEDLINE
Journal :
Neuroreport
Publication Type :
Academic Journal
Accession number :
15729143
Full Text :
https://doi.org/10.1097/00001756-200503150-00016