Back to Search
Start Over
Suppression of morphine withdrawal syndrome by interleukin-2 and its gene.
Suppression of morphine withdrawal syndrome by interleukin-2 and its gene.
- Source :
-
Neuroreport [Neuroreport] 2005 Mar 15; Vol. 16 (4), pp. 387-91. - Publication Year :
- 2005
-
Abstract
- The naloxone-precipitated withdrawal syndrome in mice and rats after intrathecal injection of recombinant human interleukin-2 protein (rIL-2) or its gene was studied. The results showed that rIL-2 could significantly decrease the number of jumps in mice. In rats, rIL-2 significantly suppressed irritating, diarrhea, weight loss, abnormal posture and salivation. Tendencies towards reductions in teeth chewing and dog-shaking were also observed. Furthermore, pcDNA3-IL-2 (8 microg DNA) had a similar effect as 1x10 IU rIL-2 protein on inhibition of morphine withdrawal syndrome in mice, and the expression of rIL-2 protein in spinal cord could be detected for 6 days. These findings provided further evidence for the neuroregulatory function of an immunological molecule such as IL-2.
- Subjects :
- Animals
Cytomegalovirus genetics
DNA, Complementary administration & dosage
Genetic Vectors
Injections, Spinal
Interleukin-2 biosynthesis
Male
Mice
Morphine Dependence genetics
Morphine Dependence prevention & control
Naloxone pharmacology
Promoter Regions, Genetic genetics
Rats
Rats, Sprague-Dawley
Recombinant Proteins administration & dosage
Recombinant Proteins biosynthesis
Recombinant Proteins genetics
Substance Withdrawal Syndrome genetics
Substance Withdrawal Syndrome prevention & control
Gene Transfer Techniques
Interleukin-2 administration & dosage
Interleukin-2 genetics
Morphine Dependence therapy
Substance Withdrawal Syndrome therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 15729143
- Full Text :
- https://doi.org/10.1097/00001756-200503150-00016