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Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2005 Mar 01; Vol. 174 (5), pp. 2756-62. - Publication Year :
- 2005
-
Abstract
- Natural selection drives diversification of MHC class I proteins, but the mechanism by which selection for polymorphism occurs is not known. New variant class I alleles differ from parental alleles both in the nature of the CD8 T cell repertoire formed and the ability to present pathogen-derived peptides. In the current study, we examined whether T cell repertoire differences, Ag presentation differences, or both account for differential viral resistance between mice bearing variant and parental alleles. We demonstrate that nonresponsive mice have inadequate presentation of viral Ag, but have T cell repertoires capable of mounting Ag-specific responses. Although previous work suggests a correlation between the ability to present an Ag and the ability to generate a repertoire responsive to that Ag, we show that the two functions of MHC class I are independent.
- Subjects :
- Alleles
Amino Acid Sequence
Animals
CD8-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes virology
Cardiovirus Infections pathology
Demyelinating Diseases genetics
Demyelinating Diseases immunology
Demyelinating Diseases virology
H-2 Antigens genetics
H-2 Antigens metabolism
Histocompatibility Antigen H-2D
Immunity, Innate genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Molecular Sequence Data
Peptide Fragments immunology
Peptide Fragments metabolism
Protein Binding genetics
Protein Binding immunology
T-Lymphocyte Subsets metabolism
T-Lymphocyte Subsets virology
Viral Proteins immunology
Viral Proteins metabolism
Antigen Presentation genetics
Cardiovirus Infections genetics
Cardiovirus Infections immunology
Genetic Predisposition to Disease
T-Lymphocyte Subsets immunology
Theilovirus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 174
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 15728484
- Full Text :
- https://doi.org/10.4049/jimmunol.174.5.2756