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Follicle-stimulating hormone bioactivity in idiopathic normogonadotropic oligoasthenozoospermia: double-blind trial with gonadotropin-releasing hormone.
- Source :
-
Fertility and sterility [Fertil Steril] 1992 May; Vol. 57 (5), pp. 1034-43. - Publication Year :
- 1992
-
Abstract
- Objective: To identify, among patients with idiopathic normogonadotropic oligoasthenozoospermia, those with low bioactive follicle-stimulating hormone (FSH), possibly because of inadequate gonadotropin-releasing hormone (GnRH) pulsatility, whose bioactive FSH and sperm could be improved by GnRH treatment.<br />Design: Randomized, double-blind, placebo-controlled trial with intranasal (IN) GnRH, followed by open GnRH treatment.<br />Setting: Outpatient endocrinology clinic.<br />Patients: Twenty-eight infertile men with idiopathic normogonadotropic oligoasthenozoospermia.<br />Interventions: Gonadotropin-releasing hormone or placebo was self-administered IN every 2 hours.<br />Main Outcome Measures: Serum immunoreactive and bioactive FSH and semen analyses.<br />Results: Ten men showed a low basal FSH bioactive/immunoreactive ratio, which increased in 5 of them under GnRH without parallel sperm modification. Sperm improvements were observed in 10 patients with no parallel evolution of FSH bioactive/immunoreactive ratio. Unpredicted by sperm changes, three pregnancies developed on placebo and 5 on GnRH.<br />Conclusions: Low bioactive FSH was not the cause of idiopathic normogonadotropic oligoasthenozoospermia in our patients and could not predict response to GnRH. Pulsatile GnRH did not improve sperm beyond random fluctuations.
- Subjects :
- Administration, Intranasal
Adult
Double-Blind Method
Female
Gonadotropin-Releasing Hormone blood
Humans
Male
Oligospermia drug therapy
Pregnancy
Pulsatile Flow
Radioimmunoassay
Sperm Count drug effects
Follicle Stimulating Hormone blood
Gonadotropin-Releasing Hormone therapeutic use
Oligospermia blood
Subjects
Details
- Language :
- English
- ISSN :
- 0015-0282
- Volume :
- 57
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 1572471
- Full Text :
- https://doi.org/10.1016/s0015-0282(16)55022-5