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Performance characteristics of four automated natriuretic peptide assays.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2005 Mar; Vol. 123 (3), pp. 439-45. - Publication Year :
- 2005
-
Abstract
- Measurement of circulating B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) can identify patients with heart failure and guide therapy. The limit of detection, linearity, imprecision, method comparison, analytic concordance, and reference intervals of the Access 2 BNP (Biosite, San Diego, CA), ADVIA Centaur BNP (Bayer Diagnostics, Tarrytown, NY), AxSYM BNP (Abbott Diagnostics, Abbott Park, IL), and E170 NT-proBNP (Roche Diagnostics, Indianapolis, IN) methods were evaluated. The Triage meter BNP assay (Biosite) was the comparison method. Imprecision testing showed total coefficients of variation of 4.1%, 4.4%, 5.5%, and 0.8% for the Access 2, ADVIA Centaur, AxSYM, and E170, respectively. Relative to the Triage meter, method comparison revealed a slope of 0.96 and r = 0.95, a slope of 0.77 and r = 0.92, a slope of 1.13 and r = 0.94, and a slope of 8.8 and r = 0.80 for the Access 2, ADVIA Centaur, AxSYM, and E170, respectively. Overall analytic concordance values with the Triage meter were 95.9%, 92.9%, 92.4%, and 84.3% for the Access 2, ADVIA Centaur, AxSYM, and E170, respectively. All automated natriuretic peptide methods showed acceptable analytic performance.
- Subjects :
- Autoanalysis instrumentation
Autoanalysis statistics & numerical data
Chemistry, Clinical statistics & numerical data
Humans
Linear Models
Reference Values
Reproducibility of Results
Chemistry, Clinical instrumentation
Natriuretic Peptide, Brain blood
Nerve Tissue Proteins blood
Protein Precursors blood
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9173
- Volume :
- 123
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 15716241
- Full Text :
- https://doi.org/10.1309/PDJ2-RMM8-0FVR-DH7W