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Interstrand photocrosslinking of DNA via p-carbamoylvinyl phenol nucleoside.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Mar 01; Vol. 15 (5), pp. 1299-301. - Publication Year :
- 2005
-
Abstract
- We report a novel interstrand photocrosslinking of oligodeoxynucleotides (ODNs). In this system, a modified ODN containing p-carbamoylvinyl phenol nucleoside reacts by photoirradiation at 366 nm with adenine residue of a complementary template ODN to yield a crosslinked ODN in 97% yield.
- Subjects :
- Cross-Linking Reagents radiation effects
Models, Molecular
Molecular Conformation
Nucleosides radiation effects
Oligodeoxyribonucleotides radiation effects
Phenols radiation effects
Substrate Specificity
Temperature
Cross-Linking Reagents chemistry
DNA chemistry
DNA radiation effects
Nucleosides chemistry
Oligodeoxyribonucleotides chemistry
Phenols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15713374
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.01.029