Back to Search
Start Over
Comparison of the effect of amphotericin B desoxycholate and amphotericin B colloidal dispersion on renal functions and renal morphology in rats.
- Source :
-
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2005 Feb; Vol. 10 (1), pp. 57-62. - Publication Year :
- 2005
-
Abstract
- Background and Aim: Amphotericin B (AmB) desoxycholate remains as one of the most efficacious agents currently available for the treatment of systemic fungal infections; however, amphotericin B colloidal dispersion (ABCD) has been developed because of AmB desoxycholate nephrotoxicity. The goal of our study was to compare the effect of administration of AmB desoxycholate and ABCD on renal functions and renal morphology in rats.<br />Results: Amophotericin B desoxycholate as well as ABCD causes damage to renal tubuli and polyuria. Amophotericin desoxycholate causes considerably more severe damage to tubuli than ABCD, but the morphological damage to renal glomeruli is minimal in both formulas. In tubular cells, AmB desoxycholate causes severe damage to mitochondria, vacuolation of cytoplasm, and increased values of volume density of peroxisomes.<br />Conclusion: None of these formulas causes a decrease in glomerular filtration in rats when animals are properly hydrated.
- Subjects :
- Animals
Cytoplasm drug effects
Cytoplasm pathology
Drug Combinations
Glomerular Filtration Rate drug effects
Kidney Tubules, Collecting drug effects
Kidney Tubules, Collecting pathology
Kidney Tubules, Collecting physiology
Kidney Tubules, Proximal pathology
Loop of Henle drug effects
Loop of Henle pathology
Loop of Henle physiology
Male
Mitochondria drug effects
Mitochondria pathology
Models, Animal
Rats
Rats, Wistar
Vacuoles drug effects
Vacuoles pathology
Amphotericin B toxicity
Antifungal Agents toxicity
Deoxycholic Acid toxicity
Kidney Tubules, Proximal drug effects
Kidney Tubules, Proximal physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1320-5358
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nephrology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 15705183
- Full Text :
- https://doi.org/10.1111/j.1440-1797.2005.00339.x