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Dietary supplementation of different doses of NUTRIOSE FB, a fermentable dextrin, alters the activity of faecal enzymes in healthy men.
- Source :
-
European journal of nutrition [Eur J Nutr] 2005 Oct; Vol. 44 (7), pp. 445-51. Date of Electronic Publication: 2005 Feb 09. - Publication Year :
- 2005
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Abstract
- Background: It is well documented that fermentation of carbohydrates that escape digestion exert several effects supposed to be beneficial for (colonic) health, including an increase in stool volume, a shorter intestinal transit time, production of short chain fatty acids and a decrease of colonic pH (Kritchevsky 1988). NUTRIOSE FB is a dextrin that is not completely hydrolysed and absorbed in the small intestine, due to many alpha-1.6 linkages and the presence of non-digestible glucoside linkages (e. g. alpha-1.2 and alpha-1.3). To be beneficial for 'colonic' health effective NUTRIOSE FB must reach the cecum in some form.<br />Aim of the Study: To estimate how much non digested NUTRIOSE FB is fermented and to determine the fibre-like effect of the wheat dextrin NUTRIOSE((R))FB by analysing enzymatic activity in faeces.<br />Methods: In a randomized, double-blind,multiple dose, placebo-controlled, combined cross-over and parallel trial, 20 healthy men (age 31.7 +/- 9.1 yrs; BMI 24.5 +/- 2.9 kg.m(-2) received different treatments. One group of ten subjects consumed on top of their diet 10, 30 and 60 g daily of NUTRIOSE FB or maltodextrin (placebo). The other group of 10 subjects consumed 15, 45 and 80 g daily. Each dose was consumed for 7 days. On the last two days of each of the 7-day period, faeces were collected in which the enzymatic activity and NUTRIOSE FB residue were analysed.<br />Results: As expected, the faecal residue of NUTRIOSE FB non-linearly increased with the dose of NUTRIOSE FB to approximately 13% of 80 g/d. Compared with the placebo, 30, 45, 60 and 80 g/d of NUTRIOSE FB increased the concentration of alpha-glucosidase significantly. All daily doses of NUTRIOSE FB (10 g/d to 80 g/d) led to significant changes in concentration of beta-glucosidase.<br />Conclusions: The small amount of the residue of NUTRIOSE FB in the faeces suggests that approximately 87% or more of NUTRIOSE FB is digested or fermented in the gastrointestinal tract. Fermentation of NUTRIOSE FB led to an increased faecal concentration of alpha- and beta-glucosidase.
- Subjects :
- Adult
Colon microbiology
Cross-Over Studies
Dietary Carbohydrates administration & dosage
Dietary Carbohydrates metabolism
Dietary Fiber administration & dosage
Dietary Fiber metabolism
Dietary Supplements
Dose-Response Relationship, Drug
Double-Blind Method
Fermentation
Humans
Male
Middle Aged
beta-Glucosidase metabolism
Colon metabolism
Dextrins administration & dosage
Dextrins metabolism
Feces enzymology
Glucosidases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1436-6207
- Volume :
- 44
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 15696402
- Full Text :
- https://doi.org/10.1007/s00394-005-0552-0