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Preoperative radiochemotherapy and radical resection for stages II-IV oral and oropharyngeal cancer: outcome of 222 patients.
- Source :
-
International journal of oral and maxillofacial surgery [Int J Oral Maxillofac Surg] 2005 Mar; Vol. 34 (2), pp. 143-8. - Publication Year :
- 2005
-
Abstract
- To analyse survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma (SCC) after multimodal therapy with preoperative radiochemotherapy (RCT) and radical surgery. We included in this analysis 222 patients who underwent multimodal therapy between 1990 and 2000. Eligible were patients with UICC disease stages II-IV (T2: 33.3%; T3: 12.6%; T4: 54.1%; N0: 45.9%; N1: 17.6%; N2: 33.3%; N3: 3.2%; stage II: 21.1%; stage III: 14.9%; stage IV: 64%). Patients received preoperative radiochemotherapy consisting of Mitomycin C (15-20 mg/m2, day 1) plus 5-Fluorouracil (750 mg/m2/24 h-infusion, days 1-5) and concomitant radiotherapy for a total dose of 50 Gy. Radical locoregional en bloc-resection according to the pretherapeutic tumour extension was carried out in all patients. After a median surveillance period of 72.3 months (24-152 months), 131 patients (59%) were alive, and 91 (41%) patients died; 12 (5%) of them died postoperatively, 46 (21%) due to tumour recurrence, and 33 (15%) deaths were not directly related to the primary tumour. Overall survival probability was 76% after 2 years, and 62% after 5 years. Two- and 5-year local control probability were 88 and 81%, respectively. Regarding the high percentage of stage IV disease in the reported patients, the multimodal concept is an effective therapy offering excellent survival and local control probability.
- Subjects :
- Antibiotics, Antineoplastic administration & dosage
Antimetabolites, Antineoplastic administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell radiotherapy
Carcinoma, Squamous Cell secondary
Female
Fluorouracil administration & dosage
Follow-Up Studies
Humans
Male
Middle Aged
Mitomycin administration & dosage
Mouth Neoplasms drug therapy
Mouth Neoplasms radiotherapy
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Oropharyngeal Neoplasms drug therapy
Oropharyngeal Neoplasms radiotherapy
Radiotherapy Dosage
Retrospective Studies
Survival Rate
Treatment Outcome
Carcinoma, Squamous Cell surgery
Mouth Neoplasms surgery
Neoadjuvant Therapy
Oropharyngeal Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 0901-5027
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of oral and maxillofacial surgery
- Publication Type :
- Academic Journal
- Accession number :
- 15695042
- Full Text :
- https://doi.org/10.1016/j.ijom.2004.04.003