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A serological study of Chikungunya virus transmission in Yogyakarta, Indonesia: evidence for the first outbreak since 1982.
- Source :
-
The Southeast Asian journal of tropical medicine and public health [Southeast Asian J Trop Med Public Health] 2004 Jun; Vol. 35 (2), pp. 408-15. - Publication Year :
- 2004
-
Abstract
- A study of epidemic transmission of Chikungunya virus (CHIK) was initiated in April 1999 in Yogyakarta, Indonesia. Three hundred seventeen volunteers from three kelurahans (sub-districts) were recruited. Anti-CHIK IgG antibodies were detected in 68% to 74% of cases and 28% to 32% of controls. In the kelurahan with no reported CHIK illness, 29% of cases and 28% of controls had anti-CHIK IgG antibodies. None of these cases demonstrated anti-CHIK IgM antibodies. In the two kelurahans with disease activity, anti-CHIK IgM antibodies were detected in 3% to 36% of cases, with the highest percentage from the kelurahan with recently reported cases. Ten percent of controls from Gowok had anti-CHIK IgM detected in their serum. Twelve acutely ill volunteers were later included from the kelurahan Pilahan for virus identification. Samples from two volunteers were culture- and RT-PCR-positive for CHIK. This is the first documentation of epidemic transmission of CHIK in Indonesia since 1982.
- Subjects :
- Adult
Alphavirus Infections blood
Alphavirus Infections virology
Female
Humans
Immunoglobulin G genetics
Immunoglobulin M genetics
Indonesia epidemiology
Male
Reverse Transcriptase Polymerase Chain Reaction
Seroepidemiologic Studies
Alphavirus Infections epidemiology
Antibodies, Viral genetics
Chikungunya virus immunology
Disease Outbreaks
Subjects
Details
- Language :
- English
- ISSN :
- 0125-1562
- Volume :
- 35
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Southeast Asian journal of tropical medicine and public health
- Publication Type :
- Academic Journal
- Accession number :
- 15691147