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The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes.
- Source :
-
The International journal of eating disorders [Int J Eat Disord] 2005 Jan; Vol. 37 (1), pp. 57-60. - Publication Year :
- 2005
-
Abstract
- Background: A short (s) allele in the promoter region of the 5-hydroxytryptamine (5-HT) transporter gene (5HTTLPR) has been associated with low transcription of the 5-HT transporter protein, and with clinical manifestations including impulsivity, affective disorder, and bulimia nervosa.<br />Methods: We studied implications of the 5HTTLPR s allele for eating symptoms, psychopathologic traits, and platelet [3H-] paroxetine binding in 59 women with bulimia spectrum syndromes.<br />Results: Compared with those without it, carriers of the s allele of 5HTTLPR showed significantly more affective instability, behavioral impulsivity, interpersonal insecurity, comorbid borderline personality disorder (BPD), and lower density (Bmax) of paroxetine-binding sites.<br />Conclusions: Our results suggest that proneness to impulsivity, affective dysregulation, and reduced central 5-HT reuptake may (in part) be codetermined by the 5HTTLPR polymorphism. However, given inconsistent 5HTTLPR expression in different populations, we speculate that we may be observing a phenotype (i.e., eating disorder)-dependent manifestation.<br /> (2004 by Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
Affect
Bulimia psychology
Disruptive, Impulse Control, and Conduct Disorders physiopathology
Disruptive, Impulse Control, and Conduct Disorders psychology
Female
Humans
Membrane Glycoproteins pharmacology
Membrane Transport Proteins pharmacology
Middle Aged
Nerve Tissue Proteins pharmacology
Serotonin Plasma Membrane Transport Proteins
Bulimia genetics
Bulimia physiopathology
Membrane Glycoproteins biosynthesis
Membrane Glycoproteins genetics
Membrane Transport Proteins biosynthesis
Membrane Transport Proteins genetics
Nerve Tissue Proteins biosynthesis
Nerve Tissue Proteins genetics
Paroxetine metabolism
Polymorphism, Genetic
Selective Serotonin Reuptake Inhibitors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0276-3478
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The International journal of eating disorders
- Publication Type :
- Academic Journal
- Accession number :
- 15690467
- Full Text :
- https://doi.org/10.1002/eat.20073