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Polyamine toxins: development of selective ligands for ionotropic receptors.
- Source :
-
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2005 Mar 01; Vol. 45 (3), pp. 249-54. - Publication Year :
- 2005
-
Abstract
- Polyamine toxins, isolated from spiders and wasps, have been used as pharmacological tools for the study of ionotropic receptors, but their use have so far been hampered by their lack of selectivity. In this mini-review, we describe how careful synthetic modification of native polyamine toxins have led to highly selective and potent new ligands for specific ionotropic receptors, particularly certain glutamate receptors subtypes, as well as nicotinic acetylcholine receptors. Moreover, the recent developments of synthetic methods, that have greatly facilitated the synthesis of polyamine toxins and their analogues are described.
- Subjects :
- Animals
Molecular Structure
Receptors, AMPA metabolism
Receptors, Nicotinic metabolism
Spiders
Structure-Activity Relationship
Wasps
Nicotinic Antagonists chemistry
Polyamines chemistry
Polyamines pharmacology
Receptors, AMPA antagonists & inhibitors
Spider Venoms chemistry
Wasp Venoms chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0041-0101
- Volume :
- 45
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Toxicon : official journal of the International Society on Toxinology
- Publication Type :
- Academic Journal
- Accession number :
- 15683862
- Full Text :
- https://doi.org/10.1016/j.toxicon.2004.11.013