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Depression and Parkinson's disease.
- Source :
-
Journal of neurology [J Neurol] 2004 Sep; Vol. 251 Suppl 6, pp. VI/24-7. - Publication Year :
- 2004
-
Abstract
- Depression occurs in approximately 45% of all patients with Parkinson's disease (PD), reduces quality of life independent of motor symptoms and seems to be underrated and undertreated. Characteristics of symptoms differ from major depression. Because of overlapping clinical symptoms, diagnosis is based on subjectively experienced anhedonia and feeling of emptiness. Available rating scales for major depression may not be adequate to correctly measure severity of depression in PD. Anxiety and depression may manifest as first symptoms of PD many years before motor symptoms. Serotonergic, noradrenergic and dopaminergic mechanisms play key roles in the etiology of depression in PD. Tricyclic and newer, selective antidepressants including serotonin and noradrenaline reuptake inhibitors (SSRI, SNRI) appear to be effective in treating depression in PD. Selective reuptake inhibitors seem to have a favorable side effect profile. Recent controlled studies show antidepressant effects of pramipexole in bipolar II depression. New dopamine agonists pramipexole and ropinirole appear to ameliorate depressive symptoms in PD in addition to effects on motor symptoms. There is a lack of appropriate rating scales and controlled studies regarding depression in PD.
- Subjects :
- Adrenergic Uptake Inhibitors administration & dosage
Adrenergic Uptake Inhibitors adverse effects
Antidepressive Agents adverse effects
Depressive Disorder physiopathology
Dopamine Agonists administration & dosage
Dopamine Agonists adverse effects
Electroconvulsive Therapy trends
Psychotherapy trends
Selective Serotonin Reuptake Inhibitors adverse effects
Antidepressive Agents administration & dosage
Depressive Disorder etiology
Depressive Disorder therapy
Parkinson Disease complications
Parkinson Disease psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0340-5354
- Volume :
- 251 Suppl 6
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 15675721
- Full Text :
- https://doi.org/10.1007/s00415-004-1606-6