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2, 3-Bis(5-alkyl-2-thiono-1, 3, 5-thiadiazin-3-yl) propionic acid: one-pot domino synthesis and antimicrobial activity.
- Source :
-
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2005 Jan; Vol. 338 (1), pp. 38-43. - Publication Year :
- 2005
-
Abstract
- In a search for promising antibacterial and antifungal compounds, two new series of 2, 3-bis(5-alkyl-2-thiono-1, 3, 5-thiadiazin-3-yl)propionic acid 1 and their corresponding N, N-dimethylpropionamide 6 have been synthesized. The reaction of 2, 3-diaminopropionate 3, carbon disulfide, formaldehyde, and the appropriate alkyl amines furnished the title compound 1. N, N-dimethylpropionamides 6 were obtained by the reaction of 1 with dimethyl amine in the presence of POCl(3). The newly prepared compounds were screened in vitro against certain strains of Gram-positive and Gram-negative bacteria and compared with nalidixic acid and ciprofloxacin. Moreover, the title compounds were tested for their antifungal activity in vitro against Candida albicans, phytopathogenic, Penicillum expansum and Trichoderma hazianum, and aflatoxin-producing Aspergillus flavus. These compounds exhibit varied activity against the tested pathogenic bacteria and remarkable inhibitory effects on growth or sporulation of some of the tested fungal species.
- Subjects :
- Anti-Bacterial Agents pharmacology
Antifungal Agents pharmacology
Aspergillus flavus drug effects
Candida albicans drug effects
Gram-Negative Bacteria drug effects
Gram-Positive Bacteria drug effects
Microbial Sensitivity Tests
Propionates pharmacology
Structure-Activity Relationship
Thiadiazines pharmacology
Thiones pharmacology
Trichoderma drug effects
Anti-Bacterial Agents chemical synthesis
Antifungal Agents chemical synthesis
Propionates chemical synthesis
Thiadiazines chemical synthesis
Thiones chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0365-6233
- Volume :
- 338
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archiv der Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 15674803
- Full Text :
- https://doi.org/10.1002/ardp.200400906