AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii.

Authors :: Ruzin A
Keeney D
Bradford PA
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2005 Feb; Vol. 49 (2), pp. 791-3.
Publication Year :: 2005
Abstract: Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 microg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 microg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the AcrAB efflux pump in decreased susceptibility to tigecycline in M. morganii.

Subjects :: DNA Transposable Elements genetics
Fluorescent Dyes
Microbial Sensitivity Tests
Molecular Sequence Data
Mutation physiology
Plasmids
Reverse Transcriptase Polymerase Chain Reaction
Tigecycline
Membrane Transport Proteins genetics
Membrane Transport Proteins metabolism
Minocycline analogs & derivatives
Minocycline pharmacology
Morganella morganii drug effects
Morganella morganii genetics

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