Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radicals: formation of S[therefore]N three-electron bonded radical complexes.

Authors :: Nauser T
Jacoby M
Koppenol WH
Squier TC
Schöneich C
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2005 Feb 07 (5), pp. 587-9. Date of Electronic Publication: 2004 Dec 10.
Publication Year :: 2005
Abstract: The one-electron oxidation of calmodulin, studied on the microsecond timescale by pulse radiolysis, leads to methionine sulfide radical cations, which complex to adjacent amide groups to form three-electron bonded intermediates.

Subjects :: Electrons
Models, Molecular
Molecular Structure
Oxidation-Reduction
Protein Structure, Tertiary
Calmodulin chemistry
Hydroxyl Radical chemistry
Methionine chemistry

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