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Body composition and metabolic changes in antiretroviral-naive patients randomized to didanosine and stavudine vs. abacavir and lamivudine.
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2005 Feb 01; Vol. 38 (2), pp. 147-55. - Publication Year :
- 2005
-
Abstract
- Comparisons of body composition and metabolic changes among antiretroviral-naive patients randomly assigned to didanosine and stavudine- (ddI+d4T) vs. abacavir and lamivudine- (ABC+3TC) containing regimens were assessed in a nested substudy of an ongoing multicenter randomized trial. At baseline and every 4 months, body cell mass and total body fat were calculated, anthropometric measurements were performed, and fasting metabolic parameters were obtained. The rates of change (unit/mo) estimated using the slopes of regression lines and overall mean changes from baseline were compared by study assignment. Among 96 patients enrolled, 46 received ddI+d4T- and 50 received ABC+3TC-containing regimens with a median follow-up of 32.4 months. For both study arms, an overall increase in the rates of change was seen for body cell mass. For ddI+d4T, after an initial increase, the rates of change declined for regional fat and total body fat compared with an increase for ABC+3TC, with the 2 arms being significantly different (P<0.05). For high-density lipoprotein cholesterol rates of change, ddI+d4T decreased, while ABC+3TC increased. For both arms, low-density lipoprotein cholesterol decreased, while triglycerides increased. Early and sustained increases in insulin and insulin resistance were seen only for ddI+d4T. In this prospective study, metabolic and body composition changes varied according to whether subjects received ddI+d4T or ABC+3TC.
- Subjects :
- Adult
Body Composition drug effects
Didanosine adverse effects
Didanosine therapeutic use
Dideoxynucleosides adverse effects
Dideoxynucleosides therapeutic use
Female
HIV Infections pathology
HIV-Associated Lipodystrophy Syndrome etiology
HIV-Associated Lipodystrophy Syndrome metabolism
HIV-Associated Lipodystrophy Syndrome pathology
Humans
Insulin blood
Insulin Resistance
Lamivudine adverse effects
Lamivudine therapeutic use
Lipids blood
Male
Middle Aged
Prospective Studies
Stavudine adverse effects
Stavudine therapeutic use
Anti-HIV Agents adverse effects
Anti-HIV Agents therapeutic use
HIV Infections drug therapy
HIV Infections metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1525-4135
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 15671799
- Full Text :
- https://doi.org/10.1097/01.qai.0000143599.64234.15