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An animal model of Kaposi's sarcoma. II. Pathogenesis of dimethyl hydrazine induced angiosarcoma and colorectal cancer in three mouse strains.
An animal model of Kaposi's sarcoma. II. Pathogenesis of dimethyl hydrazine induced angiosarcoma and colorectal cancer in three mouse strains.
- Source :
-
Anticancer research [Anticancer Res] 1992 Jan-Feb; Vol. 12 (1), pp. 113-7. - Publication Year :
- 1992
-
Abstract
- CDI, C57B1/6 and DBA2 mice were subjected to dimethyl hydrazine (DMH) carcinogenesis to determine incidences of various types of tumors developing internally in the three strains. The animals were also screened for skin angiosarcomas. Skin lesions histologically similar to cutaneous AIDS associated Kaposi's sarcoma were observed in CD1 mice. Angiosarcomas predominated over colorectal tumors in C57Bl/6 and DBA2 mice, whereas the reverse was true for CD1 mice. The visceral angiosarcomas had both histological similarities and differences with visceral AIDS associated Kaposi's sarcoma.
- Subjects :
- Animals
Body Weight drug effects
Colorectal Neoplasms chemically induced
Dimethylhydrazines
Disease Models, Animal
Hemangiosarcoma chemically induced
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Skin pathology
Species Specificity
Colorectal Neoplasms pathology
Hemangiosarcoma pathology
Sarcoma, Kaposi etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 1567155