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A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution.
- Source :
-
FEBS letters [FEBS Lett] 2005 Jan 31; Vol. 579 (3), pp. 633-7. - Publication Year :
- 2005
-
Abstract
- The mitochondrial ADP/ATP carriers (AACs) catalyze the exchange of cytosolic ADP for matrix ATP. We have identified and characterized a novel member of the AAC subfamily of mitochondrial metabolite transport proteins, termed AAC4. The AAC4 gene maps to human chromosome 4q28.1, and its product AAC4 is 66-68% identical to human AAC 1-3 and is localized to mitochondria. AAC4 transcripts are exclusively present in liver, testis and brain unlike those of AAC 1-3. Consistent with its belonging to the AAC subfamily, upon heterologous expression and reconstitution into liposomes AAC4 exchanges ADP for ATP by an electrogenic antiport mechanism with high specificity and high sensitivity to carboxyatractyloside and bongkrekic acid.
- Subjects :
- Amino Acid Sequence
Humans
Liposomes
Liver metabolism
Mitochondrial ADP, ATP Translocases chemistry
Mitochondrial ADP, ATP Translocases genetics
Molecular Sequence Data
Plasmids
Polymerase Chain Reaction
Protein Isoforms chemistry
Protein Isoforms genetics
Sequence Homology, Amino Acid
Mitochondrial ADP, ATP Translocases metabolism
Protein Isoforms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 579
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 15670820
- Full Text :
- https://doi.org/10.1016/j.febslet.2004.12.034