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Morbidity and mortality during the first two years of life among uninfected children born to human immunodeficiency virus type 1-infected women: the women and infants transmission study.
- Source :
-
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2005 Jan; Vol. 24 (1), pp. 46-56. - Publication Year :
- 2005
-
Abstract
- Objective: We evaluated morbidity and mortality during the first 2 years of life among children born to human immunodeficiency virus-(HIV) type 1-infected women enrolled in the Women and Infants Transmission Study (WITS) during an 11-year period (1990-2001).<br />Design and Methods: As part of WITS, evaluations were performed at birth and at 1, 2, 4, 6, 9, 12, 18 and 24 months of age. Growth, hospitalization and the incidence of clinical disease were assessed regularly.<br />Results: Data regarding 1118 children born to HIV-infected women (955 HIV-uninfected children and 163 HIV-infected children) were analyzed. Fewer changes in the caretaker of the child and fewer in utero exposures to drugs, tobacco and alcohol occurred in the latter periods of the study (all P values for time trend analyses <0.01). The percentages of HIV-uninfected children with poor weight gain (44 of 767; 5.7%), short stature (32 of 703; 4.5%) and wasting (27 of 792; 3.4%) were higher than expected for the general population. Two or more changes in caretaker were associated with all growth deficiencies except wasting, and fetal exposure to tobacco was associated with height abnormalities. Anemia was common and was associated with receipt of zidovudine prophylaxis. Morbidity and mortality decreased during the study period. For the uninfected children, a decrease in class A events (Kaplan-Meier rates: group 1, 22.3%; group 2, 6.8%; group 3, 4.2%; P < 0.001) and class C events and death (Kaplan- Meier event rates: group 1, 2.0%; group 2, 1.7%; group 3, 0.2%; P = 0.062) during the first 2 years of life account for the differences in the curves over time.<br />Conclusions: During an 11-year period, morbidity and mortality during the first 24 months of life decreased substantially for children born to HIV-infected women.
- Subjects :
- Adult
Child, Preschool
Drug Therapy, Combination
Female
Growth
HIV Infections drug therapy
HIV Infections physiopathology
HIV Infections transmission
Hospitalization
Humans
Incidence
Infant
Infant, Newborn
Infant, Premature
Morbidity trends
Pregnancy
Pregnancy Complications, Infectious virology
Prenatal Exposure Delayed Effects
Substance-Related Disorders complications
Anti-HIV Agents therapeutic use
HIV Infections mortality
Infectious Disease Transmission, Vertical
Pregnancy Complications, Infectious drug therapy
Reverse Transcriptase Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0891-3668
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Pediatric infectious disease journal
- Publication Type :
- Academic Journal
- Accession number :
- 15665710
- Full Text :
- https://doi.org/10.1097/01.inf.0000148879.83854.7e