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N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Feb 01; Vol. 15 (3), pp. 787-91. - Publication Year :
- 2005
-
Abstract
- The synthesis and structure-activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.
- Subjects :
- Calcium Signaling drug effects
Chemokine CCL11
Chemokines, CC pharmacology
Drug Interactions
Eosinophils drug effects
Humans
Inhibitory Concentration 50
Piperidines pharmacology
Protein Binding
Receptors, CCR3
Structure-Activity Relationship
Urea pharmacology
Piperidines chemical synthesis
Receptors, Chemokine antagonists & inhibitors
Urea chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15664858
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.11.006