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Role of the D prostanoid receptor 1 in the modulation of immune and inflammatory responses.
- Source :
-
Critical reviews in immunology [Crit Rev Immunol] 2004; Vol. 24 (5), pp. 349-62. - Publication Year :
- 2004
-
Abstract
- Prostaglandins (PGs) are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid, which are involved in numerous homeostatic biological functions and inflammation. They are generated by the sequential action of cyclooxygenase isozymes and cell-specific PG synthases. Along with their role in inflammatory responses, recent accumulating evidence strongly suggests that PGs, including PGD2, are part of a complex regulatory network that modulates the immune system. PGD2 is the major prostanoid secreted by activated mast cells and has long been implicated in allergic diseases. The aim of this review is to discuss our current understanding of the mode of action of PGD2 during Th2-mediated inflammation. We also discuss recent findings, which suggest that PGD2 exerts important effects on both immune and inflammatory responses by targeting the D prostanoid receptor 1 on dendritic cells, the most potent antigen-presenting cells.
- Subjects :
- Animals
Dendritic Cells immunology
Dermatitis, Atopic immunology
Dermatitis, Contact immunology
Humans
Inflammation immunology
Lipids physiology
Receptors, Immunologic physiology
Receptors, Prostaglandin immunology
Th2 Cells immunology
Dendritic Cells physiology
Inflammation metabolism
Prostaglandin D2 physiology
Receptors, Prostaglandin physiology
Th2 Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1040-8401
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Critical reviews in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15663363
- Full Text :
- https://doi.org/10.1615/critrevimmunol.v24.i5.30