Intraamygdaloid administration of BIBO 3304 increases water intake and extends anxiolytic effects.

The present study was designed to evaluate the effects of BIBO 3304 in the Vogel's conflict drinking test and in the water intake test in non-deprived rats after injection of the drug into the basolateral nucleus of the amygdaloid complex. BIBO 3304 was given at the doses of 25, 100 and 200 pmol/0.5 microl/site. We investigated also the effect of 5-hydroxytryptophan (5-HTP), given intraperitoneally at a dose of 20 mg/kg, which was used as a positive control in the water intake test. Water consumption was measured 1, 2, 4, 6 and 24 h after drug administration. We found that water intake was increased both after 5-HTP and BIBO 3304 administration.