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Potential risk for infection and atherosclerosis due to iron therapy.
- Source :
-
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation [J Ren Nutr] 2005 Jan; Vol. 15 (1), pp. 105-10. - Publication Year :
- 2005
-
Abstract
- Iron is an essential nutrient, but carries potential risks. Iron therapy not only affects the functions of leukocytes, endothelial cells, and cytokine production, but also causes oxidative stress and can support bacterial growth. Intravenous iron therapy may result in nontransferrin-bound iron. This may act as a catalytic agent in the formation of hydroxyl radicals, and thus potentially contribute to cell damage and atherosclerosis. Potential long-term complications of intravenous iron therapy in end-stage renal disease patients include atherosclerosis and infection, particularly in patients with iron overload.
- Subjects :
- Animals
Bacterial Infections etiology
Cardiovascular Diseases etiology
Endothelium, Vascular physiopathology
Ferritins blood
Humans
Immunity
Iron therapeutic use
Iron Deficiencies
Iron Overload complications
Lipid Peroxidation
Lipoproteins, LDL
Meat
Oxidative Stress
Renal Dialysis
Risk Factors
Atherosclerosis etiology
Infections etiology
Iron adverse effects
Kidney Failure, Chronic therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8503
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
- Publication Type :
- Academic Journal
- Accession number :
- 15648017
- Full Text :
- https://doi.org/10.1053/j.jrn.2004.09.018