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Mechanical analysis of atherosclerotic plaques based on optical coherence tomography.

Authors :
Chau AH
Chan RC
Shishkov M
MacNeill B
Iftimia N
Tearney GJ
Kamm RD
Bouma BE
Kaazempur-Mofrad MR
Source :
Annals of biomedical engineering [Ann Biomed Eng] 2004 Nov; Vol. 32 (11), pp. 1494-503.
Publication Year :
2004

Abstract

Finite element analysis is a powerful tool for investigating the biomechanics of atherosclerosis and has thereby provided an improved understanding of acute myocardial infarction. Structural analysis of arterial walls is traditionally performed using geometry contours derived from histology. In this paper we demonstrate the first use of a new imaging technique, optical coherence tomography (OCT), as a basis for finite element analysis. There are two primary benefits of OCT relative to histology: 1) imaging is performed without excessive tissue handling, providing a more realistic geometry than histology and avoiding structural artifacts common to histologic processing, and 2) OCT imaging can be performed in vivo, making it possible to study disease progression and the effect of therapeutic treatments in animal models and living patients. Patterns of mechanical stress and strain distributions computed from finite element analysis based on OCT were compared with those from modeling based on "gold standard" histology. Our results indicate that vascular structure and composition determined by OCT provides an adequate basis for investigating the biomechanical factors relevant to atherosclerosis and acute myocardial infarction.

Details

Language :
English
ISSN :
0090-6964
Volume :
32
Issue :
11
Database :
MEDLINE
Journal :
Annals of biomedical engineering
Publication Type :
Academic Journal
Accession number :
15636110
Full Text :
https://doi.org/10.1114/b:abme.0000049034.75368.4a