[Allogeneic bone marrow transplantation for a patient with malignant histiocytosis].

Authors :: Zhai M
Hu L
Chen H
Source :: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 1997 Aug; Vol. 18 (8), pp. 395-6.
Publication Year :: 1997
Abstract: Objective: To observe the efficacy and side effects of allogeneic bone marrow transplantation (allo-BMT) in the treatment of malignant histiocytosis (MH).<br />Methods: After conditioning with chemotherapy and total body irradiation, HLA-A, B, DR, DQ compatible allo-BMT was performed in a patient with MH.<br />Results: DNA fingerprinting showed engraftment on day 22, bone marrow aspiration showed hypercellularity on day 50, and no abnormal cell was found. The patient developed acute graft-versus-host disease ( II degrees) on day 40 and herpes zoster 6 months post-transplantation, and the patient has survived disease-freely for 24 months after allo-BMT.<br />Conclusion: This is the first report of treatment of MH with allo-BMT in China, showing that allo-BMT may significantly prolong the survival of MH.

Subjects :: Adult
Female
Follow-Up Studies
Histiocytic Sarcoma blood
Histiocytic Sarcoma pathology
Histiocytic Sarcoma physiopathology
Humans
Leukocyte Count
Middle Aged
Survival Analysis
Transplantation, Homologous
Bone Marrow Transplantation
Histiocytic Sarcoma surgery

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