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Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study.

Authors :
Stessman J
Maaravi Y
Hammerman-Rozenberg R
Cohen A
Nemanov L
Gritsenko I
Gruberman N
Ebstein RP
Source :
Mechanisms of ageing and development [Mech Ageing Dev] 2005 Feb; Vol. 126 (2), pp. 333-9.
Publication Year :
2005

Abstract

In an exploratory study, 11 common polymorphisms were examined for contributing to longevity including: apolipoprotein E (apoE), methylenetetrahydrofolate reductase (MTHFR), cathepsin D (CAD), superoxide dismutase 2 (SOD2), angiotensinogen (AGT) and insulin-like growth factor 2 (IGF2), Leiden factor 7, p53 oncogene, dopamine D4 receptor (DRD4) and the serotonin transporter (SERT). Genotype and allele frequencies of these genes were compared in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity to a group of 441 younger subjects (22 years). Nominally significant results provide suggestive evidence in the Ashkenazi group that apoE, MHTFR, SOD2, IGF2 ApaI, and factor VII are risk factors for a single outcome, survival to 75. Overall, the more genetically homogenous Ashkenazi ethnic group showed evidence for association in five genes examined suggesting that future studies in this population would gainfully focus on this ethnic group.

Details

Language :
English
ISSN :
0047-6374
Volume :
126
Issue :
2
Database :
MEDLINE
Journal :
Mechanisms of ageing and development
Publication Type :
Academic Journal
Accession number :
15621215
Full Text :
https://doi.org/10.1016/j.mad.2004.08.025