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Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study.
- Source :
-
Mechanisms of ageing and development [Mech Ageing Dev] 2005 Feb; Vol. 126 (2), pp. 333-9. - Publication Year :
- 2005
-
Abstract
- In an exploratory study, 11 common polymorphisms were examined for contributing to longevity including: apolipoprotein E (apoE), methylenetetrahydrofolate reductase (MTHFR), cathepsin D (CAD), superoxide dismutase 2 (SOD2), angiotensinogen (AGT) and insulin-like growth factor 2 (IGF2), Leiden factor 7, p53 oncogene, dopamine D4 receptor (DRD4) and the serotonin transporter (SERT). Genotype and allele frequencies of these genes were compared in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity to a group of 441 younger subjects (22 years). Nominally significant results provide suggestive evidence in the Ashkenazi group that apoE, MHTFR, SOD2, IGF2 ApaI, and factor VII are risk factors for a single outcome, survival to 75. Overall, the more genetically homogenous Ashkenazi ethnic group showed evidence for association in five genes examined suggesting that future studies in this population would gainfully focus on this ethnic group.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Aging ethnology
Angiotensinogen genetics
Apolipoproteins E genetics
Cathepsin D genetics
DNA Primers genetics
Factor VII genetics
Female
Genes, p53 genetics
Genetic Linkage
Genotype
Humans
Insulin metabolism
Insulin-Like Growth Factor II genetics
Israel
Life Expectancy
Longitudinal Studies
Male
Membrane Glycoproteins genetics
Membrane Transport Proteins genetics
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Middle Aged
Nerve Tissue Proteins genetics
Receptors, Dopamine D2 genetics
Receptors, Dopamine D4
Risk Factors
Serotonin Plasma Membrane Transport Proteins
Superoxide Dismutase genetics
Aging genetics
Longevity genetics
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0047-6374
- Volume :
- 126
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Mechanisms of ageing and development
- Publication Type :
- Academic Journal
- Accession number :
- 15621215
- Full Text :
- https://doi.org/10.1016/j.mad.2004.08.025