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Pulsed and continuous radiofrequency current adjacent to the cervical dorsal root ganglion of the rat induces late cellular activity in the dorsal horn.
- Source :
-
Anesthesiology [Anesthesiology] 2005 Jan; Vol. 102 (1), pp. 125-31. - Publication Year :
- 2005
-
Abstract
- Background: Pulsed radiofrequency treatment has recently been described as a non-neurodestructive or minimally neurodestructive alternative to radiofrequency heat lesions. In clinical practice long-lasting results of pulsed radiofrequency treatment adjacent to the cervical dorsal root ganglion for the management of chronic radicular spinal pain have been reported without neurologic complications. However, the mode of action is unclear. An early (3 h) effect of pulsed radiofrequency as measured by an increase of c-Fos in the pain-processing neurons of the dorsal horn of rats has been described in the literature. This effect was not mediated by tissue heating. The authors investigated a possible late or long-term effect of three different radiofrequency modalities.<br />Methods: Cervical laminectomy was performed in 19 male Wistar rats. The cervical dorsal root ganglion was randomly exposed to one of the four interventions: sham, continuous radiofrequency current at 67 centigrades, or pulsed radiofrequency current for 120 s or 8 min. The animals were sacrificed and the spinal cord was prepared for c-Fos labeling 7 days after the intervention.<br />Results: The number of c-Fos immunoreactive cells in the dorsal horn was significantly increased in the three different radiofrequency modalities as compared with sham. No significant difference was demonstrated between the three active intervention groups.<br />Conclusions: The authors demonstrated a late neuronal activity in the dorsal horn after exposure of the cervical dorsal root ganglion to different radiofrequency modalities, which was not temperature dependent.
- Subjects :
- Animals
Ganglia, Spinal cytology
Ganglia, Spinal physiology
Gene Expression physiology
Genes, fos
Immunohistochemistry
Laminectomy
Male
Pain physiopathology
Posterior Horn Cells physiology
Radio Waves
Rats
Rats, Wistar
Temperature
Ganglia, Spinal radiation effects
Posterior Horn Cells radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0003-3022
- Volume :
- 102
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anesthesiology
- Publication Type :
- Academic Journal
- Accession number :
- 15618796
- Full Text :
- https://doi.org/10.1097/00000542-200501000-00021