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Congenital hypothyroidism alters the phosphorylation of ERK1/2 and p38MAPK in the hippocampus of neonatal rats.
- Source :
-
Brain research. Developmental brain research [Brain Res Dev Brain Res] 2005 Jan 01; Vol. 154 (1), pp. 141-5. - Publication Year :
- 2005
-
Abstract
- Thyroid hormone deficiency during the critical period of neural differentiation produces permanent and severe alterations in the morphology and function of the nervous system leading to cretinism. Perinatal hypothyroidism results in permanent alterations of hippocampal synaptic functions in adult rats consequently causing learning and memory impairment. Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that regulate essential cellular activities ranging from gene expression, mitosis, programmed cell death to plasticity and memory formation, but their involvement in perinatal hypothyroidism is not determined. The present work was designed to investigate MAPKs phosphorylation in hippocampus of congenital neonatal hypothyroid rats. Congenital hypothyroidism promotes an increase in extracellular signal-regulated kinases 1/2 (ERK 1/2) phosphorylation (+50%) and a decrease in p38(MAPK) phosphorylation (-50%) without changing in Jun N-terminal kinases (JNK) phosphorylation. Therefore, the congenital hypothyroidism model disturbs ERK 1/2 and p38(MAPK) phosphorylation pathways causing an important molecular alteration in the hippocampus. This event might be related, at least partially, to the deficits in hippocampal development and cognitive functions due neonatal congenital hypothyroidism.
- Subjects :
- Animals
Animals, Newborn
Cell Differentiation genetics
Congenital Hypothyroidism enzymology
Congenital Hypothyroidism genetics
Congenital Hypothyroidism physiopathology
Disease Models, Animal
Down-Regulation genetics
Female
Hippocampus growth & development
Hippocampus physiopathology
Hypothyroidism physiopathology
JNK Mitogen-Activated Protein Kinases metabolism
Male
Memory Disorders genetics
Memory Disorders physiopathology
Mitogen-Activated Protein Kinase 1 metabolism
Mitogen-Activated Protein Kinase 3 metabolism
Phosphorylation
Rats
Rats, Wistar
Up-Regulation genetics
p38 Mitogen-Activated Protein Kinases metabolism
Genetic Predisposition to Disease genetics
Hippocampus enzymology
Hypothyroidism complications
MAP Kinase Signaling System physiology
Memory Disorders enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-3806
- Volume :
- 154
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain research. Developmental brain research
- Publication Type :
- Academic Journal
- Accession number :
- 15617763
- Full Text :
- https://doi.org/10.1016/j.devbrainres.2004.10.005