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Biphasic anti-osteoclastic action of intravenous alendronate therapy in multiple myeloma bone disease.
- Source :
-
Journal of bone and mineral metabolism [J Bone Miner Metab] 2005; Vol. 23 (1), pp. 48-52. - Publication Year :
- 2005
-
Abstract
- Multiple myeloma is a malignancy of plasma cells with osteolytic bone destruction. Bisphosphonates inhibit osteoclast activity and are widely used for the treatment of myeloma bone disease. We analyzed the changes in urinary cross-linked N-telopeptides of collagen (u-NTx) and urinary calcium (u-Ca) after bisphosphonate alendronate therapy in ten patients with myeloma bone disease. In all patients, the levels of u-Ca and u-NTx decreased within a week. After the maximum decrease of u-NTx, u-NTx started increasing in half of the patients. However, this further increase in u-NTx decreased again without any additional therapy. Disease severity and pretreatment u-NTx concentrations did not differ between patients with and without the rebound. Patients who did not have rebound had decreased bone marrow monocytes and decreased serum concentrations of interleukin 18, which is produced by monocytes. Our results suggest that impaired activity of monocytes, which are possible osteoclast precursors, is related to reduced bone destruction in multiple myeloma.
- Subjects :
- Adult
Aged
Anesthetics, Intravenous
Biomarkers, Tumor blood
Bone Diseases blood
Bone Diseases urine
Calcium blood
Calcium urine
Collagen urine
Female
Humans
Interleukin-18 metabolism
Male
Middle Aged
Monocytes drug effects
Monocytes metabolism
Multiple Myeloma blood
Multiple Myeloma urine
Osteoclasts metabolism
beta 2-Microglobulin blood
Alendronate administration & dosage
Alendronate therapeutic use
Bone Diseases complications
Bone Diseases drug therapy
Multiple Myeloma complications
Multiple Myeloma drug therapy
Osteoclasts drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0914-8779
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of bone and mineral metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 15616894
- Full Text :
- https://doi.org/10.1007/s00774-004-0540-0