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[Determination of concentration and encapsulation efficiency of silybin liposomes].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2003 Nov; Vol. 28 (11), pp. 1027-30. - Publication Year :
- 2003
-
Abstract
- Objective: To determine the encapsulation efficiency of silybin liposomes.<br />Method: After Silybin liposomes solution was separated through sphadex G-100 column, eluent collected was determined by the first derivative UV spectrometry.<br />Result: The calibration curve of Silybin was linear in the range of 0.5-30.0 mg x L(-1) (r = 0.9998). The average recovery was 101.7%. The relative standard deviation was 1.8%. The results showed that the encapsulation efficiency ranged from 65.1%-83.0% when the drug/phospholipid ratio varied from 0.02-0.06. The concentration of SLB in liposomes prepared by optimum technique was 760.4 mg x L(-1) (n = 4).<br />Conclusion: The method is accurate, simple and suitable for the quality control of Silybin liposomes.
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 28
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 15615407