Back to Search Start Over

Targeting protein kinases in cancer therapy: a success?

Authors :
Pearson MA
Fabbro D
Source :
Expert review of anticancer therapy [Expert Rev Anticancer Ther] 2004 Dec; Vol. 4 (6), pp. 1113-24.
Publication Year :
2004

Abstract

The fundamental role of kinases in cancer progression has promoted the development of a plethora of therapeutic inhibitors. Despite the promise of effective treatment with little associated toxicity, the clinical experience with these agents has been mixed. This review will summarize recent advances made in the development of kinase inhibitors to highlight emerging issues and the strategies by which they being addressed.

Subjects

Subjects :
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Clinical Trials as Topic
Humans
Neoplasms physiopathology
Protein Kinase Inhibitors pharmacology
Neoplasms drug therapy
Neoplasms enzymology
Protein Kinase Inhibitors therapeutic use

Details

Language :
English
ISSN :
1744-8328
Volume :
4
Issue :
6
Database :
MEDLINE
Journal :
Expert review of anticancer therapy
Publication Type :
Academic Journal
Accession number :
15606337
Full Text :
https://doi.org/10.1586/14737140.4.6.1113
Full Text Access
View/download PDF

Tools

Authors Abstract Subjects Details