The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma.

Authors :: Gurel A
Tomac N
Yilmaz HR
Tekedereli I
Akyol O
Armutcu F
Yuce H
Akin H
Ozcelik N
Elyas H
Source :: Clinical biochemistry [Clin Biochem] 2004 Dec; Vol. 37 (12), pp. 1117-20.
Publication Year :: 2004
Abstract: Background: We aimed to investigate the possible association between Mn-SOD polymorphism in the mitochondrial targeting sequence and asthma.<br />Methods: Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with NgoM IV.<br />Results: No significant difference in genotype frequencies was found between patients and controls.<br />Conclusion: These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with asthma.

Subjects :: Adolescent
Age of Onset
Case-Control Studies
Child
Child, Preschool
Genotype
Humans
Infant
Manganese
Oxidative Stress
Peptides chemistry
Peptides genetics
Polymorphism, Genetic
Superoxide Dismutase metabolism
Alanine genetics
Asthma genetics
Mitochondria metabolism
Superoxide Dismutase genetics
Valine genetics

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