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Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity.
- Source :
-
The American journal of clinical nutrition [Am J Clin Nutr] 2004 Dec; Vol. 80 (6), pp. 1478-86. - Publication Year :
- 2004
-
Abstract
- Background: Obesity is frequently associated with eating disorders, and evidence indicates that both conditions are influenced by genetic factors. However, little is known about the genes influencing eating behaviors.<br />Objective: The objective was to identify genes associated with eating behaviors.<br />Design: Three eating behaviors were assessed in 660 adults from the Quebec Family Study with the use of the Three-Factor Eating Questionnaire. A genome-wide scan was conducted with a total of 471 genetic markers spanning the 22 autosomes to identify quantitative trait loci for eating behaviors. Body composition and macronutrient and energy intakes were also measured.<br />Results: Four quantitative trait loci were identified for disinhibition and susceptibility to hunger. Of these, the best evidence of linkage was found between a locus on chromosome 15q24-q25 and disinhibition (P <0.0058) and susceptibility to hunger (P <0.0001). After fine-mapping, the peak linkage was found between markers D15S206 and D15S201 surrounding the neuromedin beta (NMB) gene. A missense mutation (p.P73T) located within the NMB gene showed significant associations with eating behaviors and obesity phenotypes. The T73T homozygotes were 2 times as likely to exhibit high levels of disinhibition (odds ratio: 1.8; 95% CI: 1.07, 2.89; P=0.03) and susceptibility to hunger (odds ratio: 1.9; 95% CI: 1.15, 3.06; P=0.01) as were the P73 allele carriers. Six-year follow-up data showed that the amount of body fat gain over time in T73T subjects was >2 times that than in P73P homozygotes (3.6 compared with 1.5 kg; P <0.05).<br />Conclusion: The results suggest that NMB is a very strong candidate gene of eating behaviors and predisposition to obesity.
- Subjects :
- Adult
Analysis of Variance
Chromosome Mapping
Female
Follow-Up Studies
Genetic Markers
Genetic Predisposition to Disease
Genotype
Humans
Hunger
Male
Mutation, Missense
Prospective Studies
Quantitative Trait Loci
Quebec
Surveys and Questionnaires
Chromosomes, Human, Pair 15 genetics
Eating genetics
Feeding and Eating Disorders genetics
Genetic Linkage
Neurokinin B analogs & derivatives
Neurokinin B genetics
Obesity genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9165
- Volume :
- 80
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The American journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 15585758
- Full Text :
- https://doi.org/10.1093/ajcn/80.6.1478