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Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Jan 03; Vol. 15 (1), pp. 93-8. - Publication Year :
- 2005
-
Abstract
- A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15582418
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.10.026