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[Development research on oxidase functional model iron complexes].
- Source :
-
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2004 Dec; Vol. 124 (12), pp. 873-92. - Publication Year :
- 2004
-
Abstract
- This paper describes research performed in the Laboratory of Organic Chemistry, Showa Pharmaceutical University. Oxidation reactions involving the oxidase can be divided roughly into two kinds of reactions: The first involves electron removal from an aromatic ring or an active CH-bond. The other reaction involves hydrogen abstraction from an inactive CH-bond. The oxidase models, Fe(DMF)(3)Cl(2)(1+) and Fe(AN)(6)(3+)/AN, which we have synthesized, have been shown to work by the former mechanism, and the models Fe(AN)(6)(3+)-IO(4)(-)/AN, Fe(AN)(6)(2+)-Ac(2)O-H(2)O(2)/AN, Fe(AN)(6)(2+)-2PAH-5Py-Ac(2)O-H(2)O(2)/AN, Fe(PA)(3)(OH(2))-H(2)O(2)/AN and Fe(PA)(3)(OH(2))-O(2)-electrolysis/AN do so by the latter mechanism. Further, we found some iron (II or III)picolinate-H(2)O(2)/AN complexes have the 7 alpha-hydroxylase-like activity.
- Subjects :
- Acetonitriles chemical synthesis
Acetonitriles chemistry
Carbon chemistry
Cholesterol 7-alpha-Hydroxylase
Electrolysis
Electrons
Hydrogen chemistry
Hydrogen Bonding
Hydrogen Peroxide chemical synthesis
Hydrogen Peroxide chemistry
Oxidation-Reduction
Phenol
Picolinic Acids chemical synthesis
Picolinic Acids chemistry
Iron chemistry
Models, Chemical
Oxidoreductases
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0031-6903
- Volume :
- 124
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- Publication Type :
- Academic Journal
- Accession number :
- 15577261
- Full Text :
- https://doi.org/10.1248/yakushi.124.873