Back to Search
Start Over
Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation.
- Source :
-
European journal of epidemiology [Eur J Epidemiol] 2004; Vol. 19 (10), pp. 915-21. - Publication Year :
- 2004
-
Abstract
- Background: Endothelial cell dysfunction may be related to an increase in cellular oxidative stress. Carotenoids and vitamins could have an antioxidant-mediated tempering influence on endothelial function and inflammation, thereby reducing the risk of atherosclerosis.<br />Methods: We measured serum carotenoids, alpha-tocopherol and Vitamin C concentrations in 379 subjects sampled from the general population. High-sensitive C-reactive protein (CRP), fibrinogen (Fbg) and leukocytes were measured as markers of inflammation. Furthermore, soluble intercellular adhesion molecule-1 (sICAM-1) and flow-mediated vasodilation (FMD; n= 165) were measured as markers of endothelial function. Relationships between serum carotenoids and vitamins and markers of endothelial function and inflammation were analysed after adjustment for confounding.<br />Results: In the total study group, lutein and lycopene were inversely related to sICAM-1 with regression-coefficients of -0.38+/-0.19 (p = 0.04) and -0.16+/-0.08 (p = 0.04) per 1 micromol/l, respectively. beta-Carotene was inverse related to leukocytes (-0.23+/-0.07; p = 0.007) and CRP (-1.09+/-0.30; p = 0.0003) per 1 micromol/l. Vitamin C was inverse related to CRP (-0.01+/-0.005; p = 0.04) per 1 micromol/l, whereas alpha-tocopherol was positively related to CRP (0.03+/-0.01; p = 0.02) per 1 micro/l. Zeaxanthin was inversely related to FMD (31.2+/-15.3; p = 0.04) per 1 micromol/l.<br />Conclusion: The inverse relations between carotenoids, Vitamin C and sICAM-1, CRP and leukocytes may help to explain the possible protective effect of carotenoids and Vitamin C on atherosclerosis through an influence on inflammatory processes and endothelial function.
- Subjects :
- Adult
Ascorbic Acid blood
Biomarkers blood
C-Reactive Protein analysis
Cross-Sectional Studies
Cryptoxanthins
Female
Fibrinogen analysis
Humans
Intercellular Adhesion Molecule-1 blood
Lycopene
Male
Middle Aged
Smoking blood
Vasodilation physiology
Xanthophylls
alpha-Tocopherol blood
beta Carotene blood
Carotenoids blood
Endothelium, Vascular physiopathology
beta Carotene analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0393-2990
- Volume :
- 19
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- European journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 15575349
- Full Text :
- https://doi.org/10.1007/s10654-004-5760-z