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Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania.
- Source :
-
The British journal of psychiatry : the journal of mental science [Br J Psychiatry] 2004 Dec; Vol. 185, pp. 472-8. - Publication Year :
- 2004
-
Abstract
- Background: Few controlled studies examine the treatment of depressive features in mania.<br />Aims: To evaluate the efficacy of olanzapine, in combination with lithium or valproate, for treating depressive symptoms associated with mania.<br />Method: Secondary analysis of a 6-week, double-blind, randomised study of olanzapine (5-20 mg/day) or placebo combined with ongoing valproate or lithium open treatment for 344 patients in mixed or manic episodes. This analysis focused on a dysphoric subgroup with baseline Hamilton Rating Scale for Depression (HRSD) total scores of 20 or over contrasted with non-dysphoric patients.<br />Results: In the dysphoric subgroup (n=85) mean HRSD total score improvement was significantly greater in olanzapine co-therapy patients than in those receiving placebo plus lithium or valproate (P<0.001). Substantial contributors to this superiority included the HRSD Maier sub-scale (P=0.013) and the suicide item (P=0.001). Total Young Mania Rating Scale improvement was also superior with olanzapine co-therapy.<br />Conclusions: In patients with acute dysphoric mania, addition of olanzapine to ongoing lithium or valproate monotherapy significantly improved depressive symptom, mania and suicidality ratings.
- Subjects :
- Adult
Antipsychotic Agents
Depressive Disorder drug therapy
Double-Blind Method
Drug Therapy, Combination
Female
Humans
Male
Olanzapine
Treatment Outcome
Antimanic Agents therapeutic use
Benzodiazepines therapeutic use
Bipolar Disorder drug therapy
Lithium Carbonate therapeutic use
Valproic Acid therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1250
- Volume :
- 185
- Database :
- MEDLINE
- Journal :
- The British journal of psychiatry : the journal of mental science
- Publication Type :
- Academic Journal
- Accession number :
- 15572737
- Full Text :
- https://doi.org/10.1192/bjp.185.6.472