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The versatile roles of "axon guidance" cues in tissue morphogenesis.
- Source :
-
Developmental cell [Dev Cell] 2004 Dec; Vol. 7 (6), pp. 783-93. - Publication Year :
- 2004
-
Abstract
- The Netrin, Slit, Semaphorin, and Ephrin families of secreted proteins were originally characterized in the nervous system as guidance cues for axons; however, recent studies demonstrate that many members of these families contribute to the development of a variety of organs. Here, the current knowledge of their roles is discussed with a focus on four tissues: lung, mammary, cardiovascular, and kidney. While many studies indicate a role for "axon guidance" cues in regulating cell-cell and cell-extracellular matrix (ECM) interactions during organogenesis, there is accumulating evidence that they also contribute to tissue development by regulating the transcription and translation of genes encoding key morphogenetic factors.
- Subjects :
- Animals
Cardiovascular System embryology
Extracellular Matrix metabolism
Gene Expression Regulation, Developmental
Kidney embryology
Lung embryology
Lung metabolism
Mammary Glands, Animal embryology
Models, Biological
Multigene Family
Nerve Growth Factors physiology
Netrin-1
Protein Biosynthesis
Protein Structure, Tertiary
Semaphorins metabolism
Transcription, Genetic
Tumor Suppressor Proteins
Axons metabolism
Morphogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 1534-5807
- Volume :
- 7
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Developmental cell
- Publication Type :
- Academic Journal
- Accession number :
- 15572123
- Full Text :
- https://doi.org/10.1016/j.devcel.2004.11.002