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Synthesis and antifungal activity of cholesterol-hydrazone derivatives.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2004 Dec; Vol. 39 (12), pp. 1067-71. - Publication Year :
- 2004
-
Abstract
- A series of hydrazones synthesized from various cholesterol derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved. The best results have been obtained with tosylhydrazone cholesterol derivatives 8 and 9 exhibiting activities against Candida albicans (CIP 1663-80) at a concentration of 1.5 microg/ml.
Details
- Language :
- English
- ISSN :
- 0223-5234
- Volume :
- 39
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15571868
- Full Text :
- https://doi.org/10.1016/j.ejmech.2004.07.005