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Neonatal alloimmune thrombocytopenia due to an antibody against a labile component of human platelet antigen-3b (Bak b).
- Source :
-
Transfusion medicine (Oxford, England) [Transfus Med] 2004 Dec; Vol. 14 (6), pp. 419-23. - Publication Year :
- 2004
-
Abstract
- We report the second case of neonatal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-3b (Bak(b)) antibody. The infant was severely affected with intracranial haemorrhage. Most importantly, we were able to detect this antibody only by using fresh, unfixed platelets as antigen. This antibody was detectable neither by conventional mixed passive haemagglutination, platelet immunofluorescence test using fixed platelets, nor by monoclonal antigen immobilization of platelet antigen assay using solubilized platelets. We assume that this antibody reacts only with fresh platelets and that the antigen is a labile component of HPA-3b (Bak(b)).
- Subjects :
- Female
Humans
Infant, Newborn
Infant, Newborn, Diseases diagnosis
Intracranial Hemorrhages etiology
Male
Platelet Function Tests
Purpura, Thrombocytopenic, Idiopathic complications
Purpura, Thrombocytopenic, Idiopathic diagnosis
Antigens, Human Platelet immunology
Autoantibodies immunology
Blood Platelets immunology
Infant, Newborn, Diseases immunology
Purpura, Thrombocytopenic, Idiopathic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0958-7578
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Transfusion medicine (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 15569236
- Full Text :
- https://doi.org/10.1111/j.1365-3148.2004.00537.x