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Genetic correlation between melanization and antibacterial immune responses in a natural population of the malaria vector Anopheles gambiae.
- Source :
-
Evolution; international journal of organic evolution [Evolution] 2004 Oct; Vol. 58 (10), pp. 2377-81. - Publication Year :
- 2004
-
Abstract
- The immune system of invertebrates can mount different responses, including melanotic encapsulation and several antibacterial defense mechanisms. Variation of the efficacies of these responses is generally considered to be a product of the evolutionary pressure on each response due to infection by parasites. However, potential interactions and trade-offs among the different responses of the immune system could constrain the evolutionary potential of each response. In a natural population of the mosquito Anopheles gambiae, we measured the genetic association between the melanization response and an antibacterial response in two environmental qualities (well-fed and undernourished larvae). In both environments the two immune responses were positively genetically correlated: in full-sib families that were most likely to melanize a bead, injected bacteria were most likely to be cleared. Thus, our data do not support the idea of a trade-off among different outcomes of the invertebrate immune system, but rather that some families are overall immunologically superior to others.
- Subjects :
- Analysis of Variance
Animal Nutritional Physiological Phenomena
Animals
Anopheles genetics
Anopheles microbiology
Body Weights and Measures
Escherichia coli immunology
Female
Immunity, Innate genetics
Kenya
Melanins immunology
Microspheres
Pigmentation genetics
Quantitative Trait, Heritable
Anopheles immunology
Immunity, Innate immunology
Pigmentation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-3820
- Volume :
- 58
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Evolution; international journal of organic evolution
- Publication Type :
- Academic Journal
- Accession number :
- 15562698
- Full Text :
- https://doi.org/10.1111/j.0014-3820.2004.tb01611.x