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Silencing of MDR 1 gene in cancer cells by siRNA.
- Source :
-
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2004 Oct; Vol. 23 (6-7), pp. 861-6. - Publication Year :
- 2004
-
Abstract
- Inhibition of p-glycoprotein (PGP) expression and reverse of multidrug resistance (MDR) phenotype in KB-8-5 cells by synthetic 21-bp double-stranded oligoribonucleotides were investigated. siRNA constructs for the efficient down regulation of MDR1 that are active in nanomolar concentrations and cause reversal of MDR phenotype in cells were developed.
Details
- Language :
- English
- ISSN :
- 1525-7770
- Volume :
- 23
- Issue :
- 6-7
- Database :
- MEDLINE
- Journal :
- Nucleosides, nucleotides & nucleic acids
- Publication Type :
- Academic Journal
- Accession number :
- 15560073
- Full Text :
- https://doi.org/10.1081/NCN-200026032