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Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 2004 Nov 18; Vol. 47 (24), pp. 6100-3. - Publication Year :
- 2004
-
Abstract
- A novel anti-hepatitis C virus (HCV) agent, N(3),5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine.
- Subjects :
- Antiviral Agents chemistry
Antiviral Agents pharmacology
Cells, Cultured
Hepacivirus genetics
Humans
Nucleosides chemistry
Nucleosides pharmacology
RNA, Viral antagonists & inhibitors
RNA-Dependent RNA Polymerase antagonists & inhibitors
Viral Nonstructural Proteins antagonists & inhibitors
Antiviral Agents chemical synthesis
Hepacivirus drug effects
Nucleosides chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 47
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15537363
- Full Text :
- https://doi.org/10.1021/jm0401210