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Embryonic expression pattern of the Drosophila Kallmann syndrome gene kal-1.
- Source :
-
Gene expression patterns : GEP [Gene Expr Patterns] 2004 Nov; Vol. 5 (1), pp. 67-73. - Publication Year :
- 2004
-
Abstract
- The role of kal-1, the gene responsible for the X chromosome-linked form of Kallmann syndrome, is not well definite. In Drosophila, the kal-1 gene encodes a putative protein with the characteristic kal-1 topology but with only two Fibronectin-like type III (FnIII) domains. We studied the embryonic expression pattern of kal-1 using whole mount in situ hybridization. This gene is expressed in the second half of embryogenesis showing a complex and dynamic pattern. kal-1 is expressed during important morphogenetic processes such as germ band retraction, dorsal closure and head involution. We found expression in cells associated with different sensory organs, such as the antennal organ, which has an olfactory function, the chordotonal organ, the Keilin's organ and the dorsal pharyngeal organ. Expression of kal-1 in the head also regards some ectodermal cells of the gnathal lobes. By studying the expression in Dfd and cnc homeotic mutants, we found that these ectodermal cells derive from the anterior and posterior mandibular segment, whose determination depends on cnc, and that the expression in the posterior mandibular segment requires Dfd activity. kal-1 is also expressed in the posterior part of the male gonads in a specific subset of the somatic cells called male-specific somatic gonadal precursors (msSGPs). This is the first time that the expression of a kal-1 ortholog has been demonstrated to be sex specific making the kal-1 transcript a useful tool for the study of sex determination in the gonad.
- Subjects :
- Animals
Biomarkers
Drosophila genetics
Drosophila metabolism
Drosophila Proteins biosynthesis
Extracellular Matrix Proteins biosynthesis
Female
Gonads embryology
Gonads metabolism
Immunohistochemistry
In Situ Hybridization
Kallmann Syndrome genetics
Kallmann Syndrome metabolism
Male
Organogenesis genetics
Smell genetics
Drosophila embryology
Drosophila Proteins genetics
Extracellular Matrix Proteins genetics
Kallmann Syndrome embryology
Organogenesis physiology
Smell physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1567-133X
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gene expression patterns : GEP
- Publication Type :
- Academic Journal
- Accession number :
- 15533820
- Full Text :
- https://doi.org/10.1016/j.modgep.2004.06.004